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Dr. Bogerts said in an interview with Agence France-Presse that Ms. Meinhof's brain showed evidence of "pathological modifications," which could have been used as mitigating evidence in her trial.
Alternatively, pathological modifications, including variation in vascular permeability [25], in the cochlear lateral wall are induced by acoustic overstimulation.
All these pathological modifications contribute to the pathogenesis of vascular dysfunction.
For the IGF2 gene, such pathological modifications have already been described [ 26, 27].
Mechanistic descriptions of the pathological modifications at the cellular level are investigated within VLN.
There is also evidence for pathological modifications of the muscle connective tissue.
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Seven pedal phalangeal fragments are also present but demonstrate no pathological modification.
These results indicate that bisecting GlcNAc is a novel pathological modification of BACE1 which delays its degradation.
The damage to airway function is likely due to pathological modification of the bronchial airway structures or airway remodeling.
Taken together, these data suggest that the pathological modification of BACE1, bisecting GlcNAc, blocks the lysosomal trafficking of BACE1 in the brain.
Breeding laboratory mice on food of different consistencies mimicked a natural variation in feeding ecology, whereas mice affected by the murine analogue of the Duchenne muscular dystrophy provided a case of pathological modification of the mastication process.
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