In their report, using a logistic analysis with clinicopathological variables revealed that the presence of pathological endometrial invasion, lymph node metastasis, and pathological parametrial invasion were the significant variables associated with ovarian metastasis of AC lesion.
When pathological parametrial invasion was present, the incidence increased from 3 to 25.6%.
Additionally, pathological parametrial invasion was observed in 10.8% in RH, 4.4% in mRH, and 5.3% in SH; however, there was no significant difference among three groups.
The present study indicated that pathological parametrial invasion was not an independent prognostic factor for not only OS, but also local recurrence-free survival.
High expression of CIP2A was significantly correlated with the patient's clinical stage at diagnosis, as well as with pathological microvascular invasion, but it was not significantly associated with age or HER2 status (Table 2).
Meanwhile, it is well known that at least part of these forms of adverse pregnancy outcome (APO), which mostly find their manifestation in the third trimester of pregnancy, have their origin in pathological trophoblast invasion which occurs in the first trimester of pregnancy [ 2, 4, 5].
Real-time RT-PCR and Western blotting data were analyzed by the Mann–Whitney U-test for comparisons between two groups (pT stage, metastasis, microscopic pathological vascular invasion, and serum CRP), while the Kruskal Wallis test was used to compare three groups (histological grade and treatment effect) [ 13– 15].
Neck lymph node metastasis, pathological grade, lymphovascular invasion, perineural invasion, status of surgical margin, and cross midline extension were analyzed by univariate analysis.
We then carried out univariate analyses using different covariates, including smoking and tumor size (T factor), lymph node metastasis (N factor), distant metastasis (M factor), pathological stage, pleural invasion, vascular invasion, lymphatic permeation, and histological subtype.
Only cross midline extension and the mean tumor volume were statistically associated with larger tumor volume (P < 0.05), whereas sex, age, neck lymph node status, pathological grade, perineural invasion, lymphovascular invasion, and status of surgical margin did not reach statistical significance.
