Taking the empirical multicomponent system traditional Chinese medicine (TCM) as an illustrative case, we applied NIMS to prioritize synergistic agent pairs from 63 agents on a pathological process instanced by angiogenesis.
In particular, lysosomal damage leads to lysosomal cell death (LCD) under specific physiological or pathological conditions, for instance, mammary gland involution after lactation, neutrophil aging, and bacterial infection (Sargeant et al., 2014; Loison et al., 2014; Prince et al., 2008).
The same reasoning applies to those with pathological fractures, for instance due to malignancy.
SvO2 can be above 70% in pathological states, for instance involving severe impairment in tissue oxygen diffusion.
For instance, pathological scars are stiffer relative to unwounded normal skin and typically consist of thicker collagen bundles [ 36].
Although the effect of vitamin D in some pathological conditions, for instance, chronic pains, is yet to be proved, there is a need for more supporting studies [ 7].
Under pathological conditions, for instance AAA (Choke et al. 2005; Tsamis et al. 2013), the degradation of elastin occurs faster, leading to reduced elastin concentration (Choke et al. 2005; Tsamis et al. 2013).
Evaluation of the effects of exogenous GM1 on neurogenesis and pathogenesis of AD under pathological conditions, for instance using AD model mice (Jankowsky et al., 2001), will be an interesting and fruitful subject for future studies.
We have previously shown that the presence of Alzheimer-type pathology, which may be sufficient in some instances to meet pathological criteria for AD, can occur in elderly cases of FTLD, especially those bearing Apolipoprotein E ϵ4 allele [ 25], and particularly so within unaffected regions of the posterior hemisphere [ 26].
Our data imply that it is Txnrd1 and not Txnrd2 that plays a critical role in brain development, however this does not rule out any contribution of Txnrd2, for instance under pathological conditions such as stroke and trauma.
