Sentence examples for pathological initiation from inspiring English sources

To confirm that inoculated leukemia cells did engraft bone marrow (the pathological initiation site of leukemia development), both human and mouse CD45+ cells were quantified after isolation from bone marrow of xenografted mice.

Studies have shown that the expression increases of TGFβ1 and TGFβ1 type I receptor (TβRI) is one pathological basis for initiation and development of immunologically-induced fibrosis in bovine serum albumin (BSA) [ 8].

The initiation of pathological autoimmune responses requires autoantigens to reach and trigger lymphocytes in the lymphoid organs.

Therefore, there is a need to better understand pathological mechanisms controlling both initiation and progression of SpA.

Svensson et al. (2003) showed a time-dependent contribution of microglial activation associated with p38-MAPK in the initiation of pathological pain.

The Hedgehog (Hh) signalling pathway plays an important role in cell growth and differentiation, with normal roles in embryonic pattern formation and adult tissue homoeostasis, and has a pathological function in tumour initiation and growth including foregut development.

In relation to our use of Aβ deposition in the model as the marker of the preclinical stage, we understand that primary prevention interventions should be applied before the onset of pathological changes by promoting initiation and maintenance of good health and eliminating or modifying potential risk conditions, if these are ever ascertained [ 30, 31].

Our initial data indicate that combining widely used breast tumor pathologic variables with novel tumor functional parameters of hemoglobin (assessed by using a US-NIR technique) as predictor variables may provide a powerful tool for predicting patient pathological response before the initiation of neoadjuvant chemotherapy.

The main challenge in MS remains the understanding of pathological events that lead to initiation and evolution of the disease.

However, the exact pathological processes involved in the initiation of RA remain incompletely understood.

Pathological processes involved in the initiation of rheumatoid synovitis remain unclear.