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However, their contribution in defining "physiological" versus "pathological" growth is still controversial.
Hence, the finding of RASSF1A hypermethylation in case SHPT1 could imply that this process could contribute to pathological growth in secondary hyperparathyroidism in addition to adenomas.
This tool may be an enabling technology to identify signaling events that are associated with normal and pathological growth within the context of 3D microenvironments.
Despite the availability of medical and surgical treatments for BPH there is still inadequate understanding of the processes involved in benign pathological growth of the human prostate in vivo [2].
Pathological growth of cardiomyocytes is a hallmark of failing myocardium.
Targeted biopsy was performed on patients suspected with pathological growth.
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They also occur in galls, pathological growths resulting from insect attacks.
Together with these studies, our work emphasizes that mTOR activation may not be causative of the initial development of the pathological growths that affect TSC patients.
It could be a compensatory response in those conditions, like cancer, in which p53 cannot activate gene transcription, but must induce cell death to block a pathological increase of cell growth.
Indications for surgery were cysts with large cavities, pathological fractures, growth arrest with deformities, length discrepancy of the affected limb, and absence of allograft.
Specifically, characterization of tumor predisposition syndromes with adrenocortical manifestations and molecular profiling of sporadic adrenocortical tumors have led to the discovery of key molecular pathways that promote pathological adrenal growth.
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