As the very title of the International Classification of Diseases shows, this classification can be used to encode particular diseases, syndromes, pathological conditions, injuries, difficulties and other reasons for the contact with healthcare services, i.e. the type of information that is being registered by a physician.
It appears that the level of Ki-67 expression can diagnose the malignant tumors but high multiplication capacity while pathological analysis encounters difficulty.
Wide resection is the treatment of choice, especially for GCT with extensive destruction of bone structure, recurrence, pathological fractures and difficulty in reconstruction after intralesional curettage [ 7, 10].
Cytologic examination and fine-needle biopsies are extremely unreliable in the diagnosis of MPM because of the difficulties in pathological diagnosis discussed above.
Considering the role of late sodium current in the action potential duration, mainly under pathological conditions, and the difficulty to accurately record this small ionic current, the subject of this study is highly relevant.
Bentall's approach, for instance, faces the issue of what degree of language difficulties counts as pathological, and Spaulding et al. need to find a way of distinguishing a clinical problem from a phenomenon that is normal but unwelcome.
Thus, our findings may facilitate the morphological diagnosis of clear cell ovarian carcinoma when there are difficulties in the pathological distinction between clear cell carcinomas and high grade serous or endometrioid ovarian carcinomas [ 10].
Trends are more difficult to interpret for bladder cancer than for many other cancers, because of difficulties in the pathological definition of disease, variation between cancer registries in coding practice, and changes over time in both factors.
The development of necrotizing SOL during HIV infection is a problem of pathological diagnosis, due to the difficulties arising in the differential diagnosis with neoplastic diseases and infections by other opportunistic CNS agents like T. gondii.
Vachkova and Mares remark that the interest of researchers is focused more on difficulties, problems, and pathological aspects of pregnancy that adversely affect quality of life, e.g. the varying severity of nausea and vomiting (see Table 1).
