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As the novel makes clear, the chronic family conflicts and imbalances that lead to such crises are not idiosyncratic, but rather owe their existence to the inheritance and promulgation of pathological behavioral and interpretive family systems.
This well-characterized mouse model displays the identified neuropathological hallmarks of human tauopathies, pathological behavioral phenotypes, and increased mortality [ 11, 50].
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This model was chosen because its well-characterized pathological and behavioral phenotypes mimic many key features of tau pathology in AD (Ramsden et al., 2005; Santacruz et al., 2005; Berger et al., 2007).
These results suggest that the early neuronal susceptibility to oxidative stress in the hAPP/Sod2 mice may contribute to the pathological and behavioral changes seen in this animal model.
In the 15-month-old Tg2576 mice, the transplantation of NSCs did not exert a beneficial pathological or behavioral effect.
We first described clinical, pathological and behavioral characteristics of the patients according to their POLE mutation status.
We found that mice expressing N118-82Q via the mouse PrP.Xho vector exhibit pathological and behavioral phenotypes similar to the R6/2 and N171-82Q mice.
In the current study, this new mouse model is characterized utilizing electrophysiological, pathological, and behavioral methods to evaluate the impact of model Hirano bodies on neurophysiology and cognition.
Based on these findings, we concluded that NSC transplantation in 15-month-old Tg2576 mice did not recover pathological or behavioral deficits.
Although CHI models can be considered to be very similar to majority of human TBI, they are also among the most variable with respect to input parameters, pathological and behavioral outcomes, and reproducibility among laboratories.
RNAi-mediated silencing of SKP1A in neuronal cells increases susceptibility to cell death, whereas intranigral stereotaxic injection of a lentiviral vector targeting SKP1A induces pathological and behavioral deficits in mice.
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