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In the pathologic situation of lung injury, these fibers are excessively and diffusely deposited in the mesenchyme.
The development of the secondary septae depends on the proper assembly of elastin fibers at specific sites which is deranged in the pathologic situation.
Within the further pathways which are critical for normal lung development, two vitamin-dependent signaling pathways have raised special attention: While the retinoic acid pathway is a well-known key regulator of critical steps of lung development, latest data hint that vitamin D is another positive regulator in the pathologic situation of lung damage [23 25].
In the light of our results demonstrating the GS-activating effect of ammonia, the removal of circulating ammonia via skin presents a natural continuously acting mechanism of regulation of GS activity favoring the local skin requirements for Gln in normal physiological conditions as well as in pathologic situation.
It would be interesting to investigate how to control a protein expression pattern after mRNA delivery under the different pathologic situation.
In ARVC, mutations in genes coding for cardiac desmosomal proteins affect gap junction morphology and function, and this pathologic situation is thought to contribute to the ventricular arrhythmias that characterize the disease.
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These findings suggest that TC repeat containing MS ODN could be of therapeutic use in pathologic situations due to excessive activation of immune cells.
We first discuss how several factors (receptors, signaling molecules), regulate the cytokine production, then we consider the physiologic and pathologic situations in which the cytokine network is involved.
These results elucidated the bidirectional regulation of nephrin by distinct pathophysiologic substances and may provide molecular bases for explaining how proteinuria is induced under pathologic situations and why some ligands for nuclear receptors have the anti-proteinuric potential.
Introduction Right distribution Width (RDW) has been recently proposed as a pronostic factor in different pathologic situations and especially to the septic patients who stay in ICU.
These atlases present various simulated cerebral pathologic situations (lesions) in 3D that are labeled with the resulting disorders along with the surrounding highly parcellated neuroanatomy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com