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AKW, ACK, JAH, AJK, and CDS conducted pathologic reviews and evaluations.
This is further supported by pathologic reviews of prophylactic gastrectomies in CDH1 individuals.
JAH, AJK and CDS conducted pathologic reviews and clinical data evaluations.
XD and SLei provided formalin-fixed, paraffin-embedded, archived patient materials and conducted pathologic reviews and clinical data evaluations.
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In most of cases, final pathological diagnosis was confirmed with comprehensive pathologic review and immunohistochemical staining for differential diagnosis, such as cytokeratin, TTF-1, thyroglobulin, and calcitonin 22, 23.
All patients were finally diagnosed as primary SCCTh by surgically obtained specimens or autopsies, and in most of cases, final pathological diagnosis was confirmed with comprehensive pathologic review and immunohistochemical staining for differential diagnosis (Table S1).
The limitations of this current study include its retrospective nature, the lack of centralized pathologic review, potential biases from 26% of patients with unknown stage and limited pathological and staging information.
Larger studies are needed with careful pathologic review, which has been lacking in the literature.
Six cases of unexpected mesenchymal uterine tumors were diagnosed following pathologic review of specimens obtained during hysteroscopy to evaluate intrauterine lesions.
Prior studies have demonstrated a propensity for renal cell carcinomas (RCCs) of papillary subtypes in end-stage kidneys, and perhaps in allograft kidneys, but most allograft studies lack detailed pathologic review and predate the current classification system.
Pathologic review and reporting was performed according to standards described by the TNM classification [15].
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