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Both tests "missed" one tumor with a pathologic measurement of 11.0 cm (Fig. 1d).
However, if errors in the pathologic measurement are random and do not favour MRI over the comparators (or vice versa), these estimates allow for valid comparisons (Glasziou et al, 2008).
Six cases had no information on BMI, calculated from height and weight, and 11 women received neoadjuvant treatment before the pathologic measurement of the tumour size and therefore were excluded.
Other differences suggest that included studies are more applicable to current practice (i.e. NAC with taxanes was more common), and less susceptible to changes in tumor dimensions between MRI and pathologic measurement (i.e. shorter interval between tests).
Pathologic measurements considered residual invasive components only; therefore, the definition of pathologic complete response (pCR) was standardised across studies as the absence of residual invasive cancer, with or without the presence of DCIS (i.e. a pathologic measurement of 0.0 cm) [ 20].
Although pathology is considered to be the 'gold standard', a variety of potential errors in pathologic measurement have been identified (Lagios, 2005; Provencher et al, 2012; Tucker, 2012), meaning that discrepancies with pathology may occur even when residual tumour size is accurately assessed before surgery.
Similar(53)
Observations with missing pathologic measurements were excluded.
Pooled LOA indicated that 95% of pathologic measurements fall between −4.2 cm and +4.4 cm of the MRI measurement.
For one study [ 44], MRI and pathologic measurements were provided but data for alternative tests were unavailable.
The Basal-like subtype is negative for expression of common pathologic measurements including estrogen receptor, progesterone receptor, and HER2 receptor.
Furthermore, the inclusion or exclusion of residual DCIS in pathologic measurements has the potential to affect estimates of agreement.
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