Exact(13)
Auto-immune diseases like Crohn's disease are linked to persistent, pathologic inflammation.
Targeted biologics are an appealing method to combat pathologic inflammation while avoiding non-specific immunosuppression.
By producing different inflammatory cytokines and autoantibodies, they may directly drive pathologic inflammation [ 4].
The ability to selectively modify pathologic inflammation in the injured brain without overly suppressing systemic immunity would be advantageous.
As shown in Figure 4, neither pathologic inflammation nor bleeding was observed at the site of injury three days after surgery.
IL-17 and related cytokines are direct and indirect targets of selective immunosuppressive agents for the treatment of autoimmune diseases and other diseases of pathologic inflammation.
Similar(47)
It plays a key role in counter-regulating the inflammatory response to prevent pathologic excessive inflammation (reviewed in Katz, 2007).
CHIA and CHIT1 are not the only GH18 proteins with a role to play in pathologic TH2 inflammation.
In the future, the inhibition of IL-6 and/or the restoration of RPE immunosuppression might be employed to control pathologic subretinal inflammation in AMD.
In future, the inhibition of IL-6 and the restoration of RPE immunosuppression could be used to control pathologic subretinal inflammation in AMD.
Uncontrolled activation of leukocytes and endothelial cells is a feature of pathologic chronic inflammation, such as observed in rheumatoid arthritis (RA).
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