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PXE is a good candidate for studying the impact of altered Bruch's membrane as the primary pathologic alteration in eyes of patients with PXE appears to be a thickening and calcification of this membrane [ 12, 129].
This mechanism represents a chronic pathologic alteration in muscle metabolism that is exacerbated with disease progression.
Apoptosis could result in pathologic alteration (such as neurodegenerative diseases) and could be triggered by therapeutic treatment such as irradiation or chemotherapy [ 4, 5].
Thus, the main pathologic alteration due to an indirect insult may be microvessel congestion and interstitial edema, with relative sparing of intra-alveolar spaces [ 8].
The pathologic alteration of the lung structure of TSK/+ mice represents pulmonary emphysema and is not related to hypersynthesis of collagen that is similar to the pulmonary fibrosis associated with SSc [ 35].
Developmental dysplasia of the hip (DDH) is an abnormality of the hip with pathologic alteration in size, shape, and organization of cells [ 1] and is manifested by both soft tissue (stability) and bony (acetabular) components.
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By provoking changes in the local muscle oxyhemoglobin concentration via ischemia, reactive hyperemia, drugs or muscle exercise, BOLD imaging can be used to assess physiologic and pathologic alterations of micro- and macrovascular pathologies [ 10, 16- 19].
This definition must be expanded, however, and thus we use the term mixed pathology to indicate the concomitant presence of any neurodegenerative proteinopathy and/or further pathologic alterations, including HS, vascular lesions, or other pathologies.
In addition, it has recently become evident that particle characteristics, including particle size and surface properties, are important factors in pathologic alterations and cellular responses [7 10].
A comparison of our results with the literature shows that the analyzed substances like PAHs and PBDEs probably contributed to the pathologic alterations in the investigated fish tissues.
To assess the value of the use of cardiac MRI to detect rejection (necrosis) and its ability to discriminate it from other pathologic alterations (edema and fibrosis).
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