Standardized TaqMan assays for detection of hepatitis viruses A-E have been described and applied to TaqMan Array Cards (TAC) which are capable of multiple pathogen detection using a single set of optimized PCR conditions.
Multidrug resistance (MDR) refers to the capability of bacterial pathogens to withstand lethal doses of structurally diverse drugs which are capable of eradicating non-resistant strains.
In case of microbial diagnostics, developing countries may need to jump directly to broad-range microbial diagnostic systems, which are capable of one-step detection and identification of large number of diverse pathogens in a single, highly automated, assay.
Finally, and of broader significance, we have described an approach to study host-pathogen interactions, which is capable of revealing important host response pathways that would be invisible in studies of the interaction between macrophages and pathogens in vitro.
This is especially important in the case of bacteria such as the human pathogen S. enterica which is capable of establishing a persistent infection in the C. elegans intestine [14], [15].
This nanoplasmonic technology presented a versatile, broadly applicable platform, which is capable of detecting other pathogens with reasonably well-described biomarkers available, and could be performed at multiple settings including POC settings and primary care settings.
It acts by inducing antimicrobial peptides in epithelial cells, neutrophils and macrophages 28 and increases transcription of the innate immune protein (hCAP-18) which is capable of killing a wide variety of viral and bacterial pathogens.
Most fish embryos that develop externally are exposed to an environment full of microbes, many of which are pathogens capable of killing other organisms.
The eggs in most invertebrates are fertilized externally, and therefore their resulting embryos are exposed to an environment full of microbes, many of which are pathogens capable of killing other organisms.
Candidate secreted effector proteins are defined here as small protein molecules (≤300 amino acids in length) which are putatively capable of being secreted by the pathogen via the eukaryotic secretory pathway.
