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Counteracting these protective measures, pathogens have evolved a variety of high-affinity iron scavenging systems such as siderophore production, haem and haemoglobin uptake transporters [35].
Chronic infectious diseases (e.g. malaria, tuberculosis, HIV) pose major challenges for new vaccines since these pathogens have evolved a variety of defense mechanisms that result in ineffective immunological responses to their constituent immunogens.
Enteric pathogens have evolved a remarkable array of virulence traits that enable them to colonize the intestinal tract.
However, bacterial pathogens have evolved a number of mechanisms to counter these host defenses by capturing iron from various sources.
Bacterial pathogens have evolved a plethora of sophisticated defense mechanisms to counter oxidative damage and highly toxic ROS generated from atmospheric oxygen and the oxidative burst from phagocytes.
Pathogens have evolved a number of strategies to gain entry into the host cell and to overcome the plant defense system.
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To establish and maintain a successful infection, microbial pathogens have evolved various strategies to infect the host in the face of a functional immune system.
A number of pathogens have evolved to manipulate this system in order to enhance their survival in the host [11].
Intracellular survival of bacterial pathogens determines the success or failure of an infection and bacterial pathogens have evolved to protect their intracellular niche to increase their chances of success.
We hope to gain a better understanding of how bacterial pathogens have evolved to recognize and evade host cellular processes.
Overall, microbial pathogens have evolved the capacity to intricately interface with host cells using a diversity of approaches that typically involve the exchange of biochemical signals; the net result of which is often the triggering of a host proinflammatory response.
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