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Thus, studying population genetics of pathogens has a clear applied importance toward the understanding of disease emergence through adaptation or drug resistance.
The emergence and evolution of antibiotic resistance among bacterial pathogens has a global impact on public health.
However, the presence of non-replicating pathogens has a further increased effect on virulence as the optimal replication fraction increases (Figure 2).
In support of this hypothesis, the deletion of genes in pathogens has a detrimental effect on their fitness and on their ability to cause diseases [2].
Therefore protein glycosylation in fungal pathogens has a particular significance.
Hence, development on pathogens has a hormetic effect on adult nematodes.
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These two pathogens have a common infection site the small intestine.
Studies that intentionally infect people with pathogens have a checkered past, but they are seeing a resurgence.
Fully human monoclonal antibodies directed against specific pathogens have a high therapeutic potential, but are difficult to generate.
Two proteins of these pathogens have a stretch of shared sequence with a human protein that is considered to have a uveal auto-antigen [78].
Thus, one may postulate that TLR ligands that are present in numerous pathogens have a general non specific inhibitory effect on allergic and autoimmune responses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com