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The differences between pathogens could also be seen using the total cell count.
Furthermore, outbreaks due to more common pathogens could also be missed, as for community acquired pneumonia often no causative pathogen is detected [25], [26].
However, atypical pathogens could also infect patients in a wide spectrum of severity and age.
Other residual effects, e.g., on soil-borne pathogens, could also contribute, of course.
However, pathogens could also cause diseases if they have evolved to evade detection or suppress host defense mechanisms, or both.
Finally, although our study uses aggregated data, possible regional differences in AMR patterns of pathogens could also be integrated into empiric treatment guidelines.
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New antibiotics that do not trigger a SOS response and do not lead to extensive lysis of the pathogen could also offer tools to curb the infection, as would molecules that compete with bacterial attachment to the intestinal mucosa.
This suggests that some native Gossypium populations may not only be an inoculum reservoir for the pathogen but could also nurture the pathogen's evolutionary potential.
Although, it is important to note that M. leprae is an obligate intracellular pathogen, which could also contribute to its patterns of gene loss.
The differentiability of pathogens per se could also be confirmed by corresponding GC/MS analyses of several strains (Table 3).
Even culture, species or genus identification, and antimicrobial susceptibility testing could not be substituted by this real-time PCR TaqMan assay, it could not only differentiate bacterial and fungal from viral and other pathogens, but it could also classify Gram staining with a much shorter turnaround time than the gold standard culture method.
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