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The scientists observed changes in the genetics underlying T cell activation, cell death, and the response to immune signaling molecules, suggesting that coinfection with other common pathogens changes the immune system at the genetic level.
Animal sentinels have been proposed as practical substitutes for resource-intensive surveillance systems to detect and provide early warning of the presence of pathogens, changes in the prevalence or incidence of disease/pathogens over time and to trigger disease response and control efforts (Rabinowitz et al. 2009; McCluskey 2003).
Most likely, selective pressure by pathogens changes with time.
The distribution of pathogens causing nosocomial infections, especially antimicrobial-resistant pathogens, changes with time and varies among hospitals and among different locations in the same hospital 11 – 11.
Secondary end-points included time to exacerbation, emergence of new potential respiratory pathogens, emergence of resistance among baseline pathogens, changes in inflammatory biomarkers, and change in 24-h sputum volume and colour from baseline.
The outbreak had focused attention on the need for reliable data on the incidence of infections caused by enteric pathogens; changes in the incidence over time; and estimates of the actual numbers of illnesses, hospitalizations, and deaths they cause.
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When I have asked nonscientists what they think happened when a pathogen species "overcame resistance" in a new crop variety or a new antibiotic, they often respond by saying that, well, the pathogens changed.
Causative pathogens changed little during the two periods.
The spectrum of pathogens changed during the study period with intensified perioperative antibiotic prophylaxis.
Antigenic variation and drift are mechanisms by which pathogens change their exposed epitopes while maintaining protein function.
In particular, with few exceptions, the adjusted AF and number of attributable cases for the major pathogens change only modestly, compared to the unadjusted estimates.
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