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While pathogens are recognized and often defeated by the antibacterial defense, asymptomatic carriage is the most common outcome of host-parasite interaction, creating the type of symbiosis seen with the commensal microflora.
Once microbial pathogens are recognized by various receptor or recognition factors, different signalling cascades are activated via amplifaction or supressed via dampening.
Pathogens are recognized by mucosal APCs detecting pathogen-associated molecular patterns that bind to Toll-like receptors (TLRs), initiating innate immune and inflammatory responses.
For this reason, if different ligands (i.e. pathogens) are recognized by one receptor, it is likely that more changes are observed than for receptors that recognize only one ligand.
Parasites and pathogens are recognized as a major evolutionary force, and all living organisms face a continual struggle to fend off immunological insults within their environment reviewed in [ 1, 2].
It is also likely that pathogens other than the ones we tested for (possibly including pathogens not yet known) caused a proportion of these illnesses, and will become important public health targets in the future as new diagnostic tests become available and, also, potentially as new pathogens are recognized.
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Cytosolic DNA, a PAMP resulting from infection with DNA-containing intracellular pathogens, is recognized by a yet unknown number of DNA receptors.
In the 1950s and early 1960s these studies were hampered by the fact that only a relatively few diarrheal pathogens were recognized and they were recovered from only a small proportion of diarrhea cases [ 28– 33].
Activated monocytes that are phagocytizing pathogens were recognized as one type of APCs; APCs display major histocompatibility complex class II (MHCII) peptide on the surface available for binding to T cell antigen-specific receptor (TCR) [ 77].
Next, we tested if our murine TAP transport predictions could identify which peptides contained in a pathogen are recognized as T cell epitopes.
When a particular motif from the pathogen is recognized by such a plant receptor, the plant efficiently triggers inducible systems that lead to resistance.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com