Our collective findings contribute towards understanding the potential main steps in phytoplasma pathogenicity pathway.
Like other Gram positive pathogenic bacteria, several general pathogenicity-related pathways were also identified at the genomic level, besides those documented as virulence-associated factors (VAF)[1], [2], such as capsular antigen (CPS), suilysin, extracellular protein factor (EF), muraminidase-released protein (MRP), and glutamate dehydrogenase (GDH).
Our pathogenicity interpretation pathway predicted 13 different mutations in eight different genes: PRKCG, TTBK2, SETX, SPTBN2, SACS, MRE11, KCNC3 and DARS2 of which nine were novel including one causing a newly described recessive ataxia syndrome.
Most of the Salmonella based vaccines generated till date has been created by deleting essential genes of the metabolic pathway, pathogenicity islands or global regulators.
To this end, we built VariantDB, a web-based interactive annotation and filtering platform that automatically annotates variants with allele frequencies, functional impact, pathogenicity predictions and pathway information.
This result highlights the genomic diversity within pathogenic E.coli, and that there are many different evolutionary pathways to pathogenicity.
Thus, the objective herein was to use whole genome sequencing and analysis of M. suis to define pathogenicity mechanisms and biochemical pathways.
The dissemination of antibiotic resistance genes on a global scale is the paradigm, but examples of disseminated gene clusters for metabolic pathways and pathogenicity determinants also exist [6], [7].
G protein alpha subunits have been comprehensively studied, as a key component of signal transduction pathways and pathogenicity [ 46].
In this study, we show that INPP1 drives cancer pathogenicity through controlling glycolytic pathways that feed into the generation of oncogenic signaling lipids.
