A large number of distinct types of bacteria with different pathogenicity increase periodontal inflammation.
Sputum collection predominately arises from the larger airways; thus, our results cannot infer causality of detectable pathogens and increased inflammation in the pathogenicity of COPD, a predominately small airways disease.
Glycosylation of viral surface antigens is critical for immune recognition, receptor binding, inflammation, and pathogenicity, and therefore has a major influence on the efficacy of vaccine antigens [31], [32].
Furthermore, whole genome sequencing of multiple P. acnes strains has provided valuable insights into the range of putative virulence factors and proteins that may facilitate attachment, inflammation, and pathogenicity [ 6, 7].
Mutant viruses with loss of 158N or 169N glycosylation sites showed increased pathogenicity, systemic spread and pulmonary inflammation in mice compared to the wild-type H5N1 virus.
T-cell derived GM-CSF is required for T-cell derivedation of monocyte-derived inflammatory dendritic cells during inflammation and for the pathogenicity of is-17 prequired T helper cells in autoimmunity.
Clinically, EBOV infection can result in exaggerated inflammatory responses and multiorgan damage, although the pathogenesis (including the inflammatory pathogenesis) and the viral virulence factor(s) involved in the excessive inflammation induction and viral pathogenicity are largely unclear.
These findings suggest the possible involvement of IL-22 and IL-17 in the inflammation that contributes to pathogenicity of AMD, and C5a may be one of the factors contributing to the elevated serum levels in AMD patients [ 14, 15].
Two laboratories recently reported that the SPI-2 pathogenicity island also contributes significantly to cecal inflammation [27], [16].
Cancer risk is increased in relation to the ability of the infecting strain to cause inflammation (eg, those possessing the Cag pathogenicity island).
