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Gochang1 virus has been shown to be highly pathogenic for chickens (intravenous pathogenicity index 3.0) (6 ).
Both viruses were shown to be highly pathogenic for chickens (intravenous pathogenicity index 3).
ICU: intensive care unit; IPI: intrinsic pathogenicity index; PPM: potentially pathogenic microorganisms; SDD: selective decontamination of the digestive tract; SOD: selective oropharyngeal decontamination; VAP: ventilator-associated pneumonia.
This clade 1 isolate bears a PQRERRKKR/GLF motif at the HA0 cleavage site, and has an intravenous pathogenicity index (IVPI) of 2.9 in specific pathogen free (SPF) chickens; in addition, it has been found to induce clinically overt and lethal neurological disease in adult Pekin ducks (Harder et al., unpublished).
The corresponding isolate, A/Turkey/Suzdalka/Nov-1/05, from turkey spleen was highly pathogenic for chickens in the laboratory intravenous pathogenicity index test.
*IVPI, intravenous pathogenicity index (1 ); LPAI, low pathogenicity avian influenza; HPAI, highly pathogenic avian influenza.
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The IVPI was calculated from the mean score and used to assign one of three pathogenicity indices: highly pathogenic, non-pathogenic or intermediate.
All HPAI H5 viruses were highly pathogenic in SPF chickens (intravenous pathogenicity indices: 2.74 3.0) (Supplementary Table S3), which exhibited disease signs typical of those infected with HPAI A(H5N1) viruses.
The intravenous pathogenicity indices of the viruses were 2.34, 0.0 and 0.07 for WT, Mut1 and Mut2, respectively.
In addition, the cytotoxic H. pylori strains decrease the ATPase activity of HeLa cells, which correlates with the severe damage and increased pathogenicity indices of the patients.
The decreased activity of ATPase enzyme or the release of cytotoxin also correlated with the increased pathogenicity indices of the patients.
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