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It is important to discriminate between prion strains because they exhibit distinct interspecies transmission properties, and in particular different pathogenicity for humans [11], [12].
B. melitensis and B. suis are the most pathogenic, whereas B. abortus is considered of moderate pathogenicity, and B. canis is considered of low pathogenicity for humans.
Another possibility yet to be explored is that different strains of B. dermatitidis exist that are better adapted to certain environments and that may vary in their pathogenicity for humans.
Pathogenicity for humans is, as yet, unknown.
Hantaviruses possess strikingly different degrees of pathogenicity for humans.
The correlation between these three viruses and their pathogenicity for humans are not yet known (9).
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The high frequency of 'immune' individuals with no disease or outbreak history raises questions as to the real pathogenicity of ZEBOV for humans in 'natural' conditions.
Furthermore, high-pathogenicity markers for human-adapted influenza virus, such as an E637K amino acid substitution in the PB2 gene and Q226L in the haemagglutinin (HA) gene, have been identified in recent isolates of the H7N9 virus, suggesting that the virus might become more virulent in humans.
Being able to use plant models to study pathogenicity of human pathogens relies on the microbial capacity for cross-kingdom pathogenicity [15], [18].
The bovine and human tubercle bacilli differ in many ways in their pathogenicity for animals and humans.
Reassortment event are known to play a major role in the emergence of new influenza virus strains, leading to major changes in pathogenicity for animals and humans alike.
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