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The list of prioritized variants included also those ones showing the same pathogenicity features of the 'Top 14 LHON-causative mutations' (Table 2).
While initially useful for the elucidation of some general pathogenicity features of the Ustilaginaceae (Kämper et al. 2006; Schirawski et al. 2010; Laurie et al. 2012) it thus seems reasonable to focus more on the nonclustered putative-secreted effector genes in future studies.
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palearctica strains do not carry the already defined high-pathogenicity associated features of 8081 O 8/1B ([ 50]).
This first paper, however, did not describe pathogenicity-related features shared by X. albilineans and other species of Xanthomonas.
pneumoniae epidemiologically well defined isolates from West Africa with the aim of providing insights into the pathogenicity and other features related to the biology of the organism.
We applied comparative phylogenomics (whole genome comparisons of microbes using DNA microarrays combined with Bayesian-based phylogenies) to investigate S. pneumoniae isolates from West Africa, with the aim of providing insights into the pathogenicity and other features related to the biology of the organism.
The other 30 (75%) code for determinants not known to be involved in pathogenicity, but including features compatible with an ancient mobile elements [ 10], such as a transposase gene (spy2013), two 11-bp direct repeats (starting at positions 1663812 and 1710243), and the vicinity of Lys-tRNA gene as a putative insertion/excision site.
To this end, we listed and described all predicted pathogenicity-related genomic features and compared, by suppression subtractive hybridization (SSH), two strains of X. albilineans that differ in pathogenicity.
The present manuscript on the same genome sequence aims to describe all other pathogenicity-related genomic features of X. albilineans, and to compare, using suppression subtractive hybridization (SSH), genomic features of two strains differing in pathogenicity.
We also find that the SHI-1 pathogenicity island a distinguishing feature of serotype 2a (the dominant serotype causing disease world-wide [ Kotloff et al., 1999])—was acquired once (between 1848 and 1882) near to the root of PG3.
These proteins play different roles in mycobacterial pathogenicity and possess featured values of antigenicity and immune response induction; in addition, the PE_PGRS49 candidate is not present in M. bovis or in the BCG proteome, an important characteristic that could be useful in the improvement of a specific immune response against pulmonary disease in the current BCG vaccine.
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