No molecular markers for pathogenicity (e.g. PB2 E627K) were detected.
Most of the small number of protein families found to be overrepresented in M. abscessus are known to be associated with mycobacterial pathogenicity (e.g. PE and PPE proteins, MCE and YrbE proteins, lipoprotein LpqH precursors, lipases/esterases/monooxygenases).
Many genes on the O-islands are important in pathogenicity (e.g., genes on the LEE islands) [ 33].
I have read that TAS often flank pathogenicity islands (e.g. [ 107]), and have wondered about chromosomal TAS modules performing guard functions for neighboring genes.
Prior to sequencing, the pathogenicity of E-Pae 2250 was confirmed by inoculating a cell suspension onto wounded horse chestnut shoots and observing subsequent development of lesions.
Furthermore, S. aureus strains defective in certain cell wall components known to be important for pathogenicity [e.g., lipoteichoic acid [18], wall teichoic acid [19], extracellular adherence protein [20]] were not impaired in their ability of inducing HIF-1 activation (Fig. 5).
They are important determinants of pathogenicity [e.g. NCBI: NP_521723 and NP_522144; [ 1]].
In some studies, a connection of the regulation of phages and the LEE pathogenicity island was found (e.g., [ 66, 67]).
Several Acinetobacter strains recovered so far harbor plasmid molecules, some of which have been correlated to the peculiar adaptation to environmental conditions (e.g., pathogenicity, resistance to heavy-metals and antibiotics, biodegradation of hydrocarbons).
Homology searches revealed that several ESTs were homologous to known fungal pathogenicity or virulence factors (E-value < 1e-5), including key components of signal transduction pathways, transporters, and genes involved in infection-related morphogenesis (Table 2).
If and when additional and important new information pertaining to a specific mutation entry becomes available (e.g. questionable pathogenicity, confirmed pathogenicity, additional clinical or laboratory phenotypes, population frequency data, supporting functional studies, etc)., then the mutation entry may be revised or even re-categorized.
