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New methods based on Dynamic Bayesian Network (DBN) machine learning were employed to conduct a comparative pathogenicity analysis of 219 signaling and metabolic pathways and 1620 gene ontology (GO) categories that defined the host's biosignatures to each infectious condition.
Pathogenicity analysis, however, has been mainly focused on Y. enterocolitica serobiotype O 8/1B, of which a complete genome sequence is available (strain 8081, [ 15], accession no. NC_008800.1 and NC_008791 (plasmid)).
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However in order to ascertain its pathogenicity, further analysis of large genomic rearrangements in BRCA1/2 genes, as well as segregation analysis in the family of the patient need to be performed.
Although the identification of PHI genes in the genome wide and pathogenicity variation analysis in transcriptome level were performed, there are still some limitations in this work.
We present our comparison of multifactorial likelihood predictions of pathogenicity and functional analysis of these BRCA1 variants.
In addition to pathogenicity and virulence analysis, the S. typhimurium metabolic reconstruction can be a valuable tool to interpret several 'omics' data types.
This novel mutation has not been previously reported and we categorized the mutation as "possible pathogenicity"; a functional analysis is still ongoing.
We isolated a virulent IBV strain from 30-day-old broiler chickens in the Yunnan Province and characterized it using sequence alignment, phylogenetic analysis, pathogenicity studies, histopathologic observation, and immunohistochemical (IHC) examination.
All H5 and H7 viruses were determined to be low-pathogenicity AIVs by analysis of the amino acid sequence at the HA protein cleavage site.
As expected from the pathogenicity tests, nucleotide sequence analysis corresponding to the HA1/HA2 junction of these viruses revealed no poly-basic cleavage motif.
As detailed in Table 1, the data indicate that evolutionary analysis supported pathogenicity for all variants.
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