Worldwide the entire human population is at risk of infectious diseases of which a high degree is caused by pathogenic protozoans, worms, bacteria, and virus infections.
These observations were supported and extended by demonstrating that DMDS can suppress the growth of Agrobacterium strains in vitro ([ 9] and this work), as well as mycelial growth of several plant-pathogenic fungi, worms (C. elegans), and insects (D. melanogaster).
The pathogenic bacteria kill worms in 4 hr (Zhang et al., 2005) and thus, it would be detrimental for worms to increase consumption of the bacteria.
Previous efforts to express wild type or pathogenic hαSyn in worms led to loss of the fluorescent DAergic neuron marker due to degeneration of DAergic neurons [5], [20].
Further, nematode sensitivity to the cues of pathogenicity appears to require training by prior exposure to non-pathogenic bacteria: naïve worms were attracted to the most virulent strains, whereas worms that had been fed bacteria were much more discriminating.
However, the results obtained during the survey showed the presence of highly pathogenic GINs, high worm burden in all sector of gastrointestinal tract and high prevalence values.
Some bacterial species are pathogenic [33], [34], and worms can learn to avoid pathogenic food sources [13].
Furthermore, we found that despite P. aeruginosa's relatively high transmission rate among worms, its pathogenic effects reduced the overall number of worms colonized.
P. luminescens lives symbiotically in the nematode gut, but also has a pathogenic phase when the worm, which normally resides in the soil, infects an insect.
Previous results in yeast [ 23, 38], fruit fly and worm [ 39], pathogenic bacteria [ 40, 41], cyanobacteria [ 42], mouse macrophages [ 43], mouse blood [ 44] and human cell culture [ 2, 7] support the notion that our approach is generally applicable, though these have been focused on analysis of coexpression networks from transcriptomics.
