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Conventional approaches are not yet capable of creating unattended sensors that can selectively detect pathogenic viral and bacterial agents.
High fidelity viral strains that produce less heterogeneous and less pathogenic viral populations are under study as new poliovirus vaccine candidates [12].
However, non-synonymous mutations not eliminated by purifying selection might result in pathogenic viral variants that accelerate the progression of disease.
The pathogenic viral replication was associated with the emergence of viruses that were recombinants between the vaccine virus and the challenge virus SIVsmE543-3 and was associated with an increased glycosylation of viral spikes (Figs. 7 and 8).
Although viral hepatitis is an "old" problem, the understanding of viral hepatitis remains vague even as attention is paid to newly emerging and highly pathogenic viral diseases that have been the recent focus of public health efforts.
However, the clinical [44], [45], and genotype-phenotype relationships observed herein and previously [39] raise the possibility that for a therapeutic vaccine to be efficacious in mitigating disease progression rates, in addition to reducing the viral load, the vaccine may also need to target pathogenic viral load-independent factors.
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Although recent data have significantly advanced our understanding of the pathogenesis of this disease, the molecular events involved in the progression from non-pathogenic viral infection to MCC development remain unclear.
Some immunotherapeutic approaches use non-pathogenic viral or bacterial components as modifiers of the immune response.
This article reviews current knowledge on therapeutic applications of antisense and RNA interference for highly pathogenic RNA viral infections.
Eight highly pathogenic H5N1 viral isolations were collected from different areas of Thailand between 2003 and 2006, and were used for analysis of H5N1 genotypic testing with a semiconductor-based oligonucleotide microarray.
Pathogenic genes, viral and bacterial, are labeled with luciferase and are transferred to animals to generate desired animal disease models.
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