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However, TTN truncations can also be found in the healthy population, which gives some uncertainty to the pathogenic value of such variants.
In conclusion, we strengthen that the functional analyses of the missense variants found by us are still missing and would help us to clarify the real pathogenic value of these mutations in our population.
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Pathogenicity values, ranging from 0 to 1, allowed discriminating between potentially pathogenic and neutral mutations.
However, further basic or clinical studies are needed to test the pathogenic or diagnostic values of LCN2 expression.
The p value for pathogenic CNVs only (p = 0.0013) and for pathogenic and likely pathogenic combined category (p = 0.0024) also reached statistical significance.
The five 15-mer SUAM epitopes selected by bioinformatic analysis were produced to evaluate the immunogenic value and pathogenic role of these putative domains.
The aberrant production of a broad heterogeneous group of autoantibodies is a serological hallmark in SLE; a great effort has thus been made to understand the pathogenic, diagnostic, and prognostic value of these autoantibodies since they were discovered [ 2– 4].
The chaperone and usher proteins have significant sequence similarities with their counterparts in the pathogenic Bordetellae, with e-values ranging from 6e-23 to 3e-35 for the chaperones and e-values ranging from 3e-71 to 6e-103 for the usher proteins.
Table 1 lists the MIC values for potentially pathogenic bacteria; Table 2 summarizes the MIC values for multiresistant bacteria.
169 and 171 exhibited considerable antibiotic activity against Gram positive pathogenic bacteria with MIC values ranging between 4 and 16 μg/mL.
PR3-ANCA have proven diagnostic value but their pathogenic potential and utility as a biomarker for disease activity remain unclear.
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