While these data do not directly indicate that aggregates themselves are pathogenic, they support the body of the literature showing that truncated forms of mutant htt produce neurological abnormalities in vivo.
This fact, together with the unusual resistance to degradation by conventional agents of pathogenic PrPSc, supports the notion that prions may persist for long periods of time in soil [24], [25], thereby increasing the probability of intraspecies or interspecies transmission.
The structural conservation among effector candidates from diverse plant pathogenic species supports the hypothesis of an ancient common ancestor.
In the conditions of intact integuments integrity, the epidermis acts as a mechanical barrier against pathogenic microorganisms supported by the acidic environment and physiological bacterial flora on the skin surface.
The over-expression of ApMIFs was observed in two distinct aphid clones and after exposure to both parasitoids and pathogenic bacteria, supporting a general involvement of ApMIFs in aphid's immune response, regardless of the aphid genetic background or of the pathogen.
More recently, however, studies of adoptive transfer EAE using polarized Th1 and Th17 cells support pathogenic roles for either subset.
These data provide insight into the potential role played by T3E genes for pathogenic bacteria and support a "repertoire for repertoire" hypothesis that may explain host specificity.
While the effects as discussed below suggest the possibility that this novel mutation is pathogenic, the genetic support is inconclusive.
While the observed effects on Aβ processing suggest the possibility that this novel mutation is pathogenic, the genetic support is inconclusive.
Our data are consistent with evidence from other studies that point to NMJ alteration as an early pathogenic event and support the validity of the T70I zebrafish model (Fischer et al., 2004; Dupuis et al., 2009; Dupuis and Loeffler, 2009; Ramesh et al., 2010).
The possibility that this mutation is not pathogenic has been supported by two subsequent works [35, 36].
