Sentence examples for pathogenic step from inspiring English sources

Studies in MS postmortem tissue have also indicated that oligodendrocyte apoptosis may be an important pathogenic step in a subset of lesions [48].

The resulting impaired cathepsin B mediated trypsinogen activation seems not be a pancreatitis promoting pathogenic step.

Experimental studies have shown that microcirculatory dysfunction, a consequence of endothelial activation, is an early pathogenic step.

Compelling data implicate angiogenesis and tumor-associated neovascularization as a central pathogenic step in the process of tumor growth, invasion and metastasis.

Although PspC seems to have a limited impact in the PM model, our data do not exclude a possible role in crossing the BBB, an early pathogenic step bypassed by i.c.

Finally, inflammation may be due to the pancreatitis and thus a pathogenic step towards the development of pancreatic cancer, or it may be a consequence of the pancreatic cancer itself.

To identify the initial pathogenic steps in CWV, Atlantic salmon fry were differentially immersed in a suspension of A. (V).

The focus of the Montine Laboratory is on the structural and molecular bases of cognitive impairment with the goal of defining key pathogenic steps and thereby new therapeutic targets.

Although the exact pathogenic steps leading from venous hypertension to venous ulceration remain unclear, several hypotheses have been developed to explain the development of venous ulceration.

The development of bacterial meningitis includes several pathogenic steps, involving mucosal colonization in the gastrointestinal tract, microbial translocation of the mucous membrane and invasion of the intravascular space with subsequent intravascular survival and accompanied bacteremia.

The loss of genomic stability and resulting gene alterations are key molecular pathogenic steps that occur early in tumorigenesis: they permit the acquisition of a sufficient number of alterations in tumor suppressor genes and oncogenes that transform cells and promote tumor progression.