Sentence examples for pathogenic state from inspiring English sources
Our data indicate that rHsp65 is one of the managers with a significant impact over the immune response during autoimmunity, skewing it to a pathogenic state, promoting both Th1 and Th17 commitment.
CD4+ T cells from persistently infected deer mice display a Foxp3+ phenotype, indicative of T regulatory cells, and this may be a mechanism in which the deer mouse avoids an inflammatory-mediated pathogenic state [43].
Our data suggest that Hsp65 has pathological significance during the ocular autoimmune disease by increasing the immune response associated with an expansion of CD4+IFN-γ+ and CD4+IL-17+ T cells, probably by skewing it to a pathogenic state, promoting both Th1 and Th17 commitment.
B. burgdorferi, the causative agent of Lyme disease, has a complex life cycle in which the microbe resides in widely divergent environments that include the midgut of the Ixodes tick, tick salivary glands, and in its pathogenic state within the mammalian reservoir when passed to the inadvertent human host [1].
This pathogenic state was caused by the impairment of PINK1-mediated mitophagy.
Transformation to pathogenic state maybe due to exchange of DNA fragments between bacteria [ 14].
Discriminating between commensal and pathogenic states of opportunistic pathogens is critical for host mucosal defense and homeostasis.
The factors determining the balance between its commensal and pathogenic states are not understood.
Gut flora, which can vary dramatically between obese and lean individuals [46], [47], could also serve as a source of TAS2R stimuli in normal or pathogenic states.
In addition to normal cell functions, furin is implicated in many pathogenic states, because it processes to maturity membrane fusion proteins and pro-toxins of a variety of both bacteria and viruses, including anthrax toxin.
We further posited that such environment-induced adaptations are brought about by 'system status changes' (rewiring of pre-existing cellular signaling networks and components) of the host and the microbe, and that prolongation of such a situation could lead to the emergence of pathogenic states in real-life.
