This represents an important knowledge gap, since these antibodies are disease-specific, have significant prognostic and pathogenic significance and are increasingly recognized to characterize a unique subset of patients with RA [ 22, 23].
Hyperreflective foci (HRF) in the outer retina are associated with the progression of multiple retinal diseases, but their pathogenic significance in retinitis pigmentosa (RP) remains obscure.
Determining the basis for AV accumulation is critical for understanding the pathogenic significance of autophagy in a given pathologic state and for designing possible therapies based on modulating autophagy.
Additional genes with pathogenic significance in prostate cancer have been identified by analysis of cDNA microarrays comparing benign and malignant prostate tissue, by differential genetic analysis of benign and malignant prostatic epithelium, and by induction of experimental prostate cancer in genetically engineered mice.
The pathogenic significance of these cells is not known, but they seem to represent selective activation of the immune system in patients with untreated hyperthyroid Graves' disease.
Previous studies have frequently reported increased serum troponin levels in some marathon finishers, although the pathogenic significance of such observations has remained unknown [5, 7, 35 37].
Nevertheless, in SSc an imbalance between compartments seems to characterize patients with interstitial lung disease, but the pathogenic significance of these data remains to be elucidated.
The pathogenic significance of these observations still needs to be clarified.
However, certain other characteristics of the CD4+CD28null cells, seen here in greatest proportions among the IPF patients destined for poor outcomes, may have potential pathogenic significance.
Therefore, it is important to understand the molecular mechanism(s) underlying the seeding function of amyloid oligomers, whose pathogenic significance in protein misfolding diseases have been well supported.
Future studies intending to increase the depth of sequencing in this zoonotic lineage will help unravel the pathogenic significance of sequence variation.
