Exact(2)
As a result, there is a higher probability that there will be a single (or only a few) pathogenic route(s) to the EOD syndrome (see Figure 2).
Gene profiling of salivary gland tissue in relation to B-cell depletion confirms that the axis of IFNα, B-cell activating factor, B-cell activation, proliferation and survival constitutes a major pathogenic route in pSS.
Similar(58)
Understanding basic intermediary metabolism and its links to mitochondrial function and disease may well reveal similar pathogenic routes underlying progressive disorders.
These results suggest that the epigenetic signatures related to unhealthy obesity may involve nutritional factors, as well as point to possible new pathogenic routes to obesity-related diseases with implications for treatment.
DIO3 and FOXD2 are two novel genes that are differentially methylated and expressed in CC, SAC and another endpoint of the serrated polyps pathway as it is the CRC showing molecular and histology features of MSI-H, and thus, they may serve as novel interesting diagnostic markers, pathogenic routes tracers or molecular targets.
The recognition of large, non-coding expansions in an increasing number of neuromuscular disorders (Matsuura et al., 2000; Sato et al., 2009; Dejesus-Hernandez et al., 2011; Renton et al., 2011) has raised interest in the pathogenic routes mediated by repetitive RNA elements (Krzyzosiak et al., 2011).
Biological viruses can mutate rapidly, create novel pathogenic and transmission routes, and develop antigenic variation to evade host immunity.
Further studies to gain better understanding of pathogenic mechanism and transmission route of F. novicida are necessary to provide appropriate guidelines for the treatment and prophylaxis.
It is not known at present whether S. paratyphi B, monophyletic or polyphyletic as it may turn out to be, has a stable or plastic genome structure; however, it may too have followed a similar route of pathogenic evolution.
All mutations included in the study that were shared across sites were classified as pathogenic according to both routes of definition.
Regarding involvement of the proteins found mutated in FALS pedigrees in sporadic ALS, these proteins possibly occupy different steps or occur in parallel routes in pathogenic chains of events.
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