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Also, a pathogenic role for BDNF has been shown in pain transduction and sensitization, in epilepsy, and in neuropsychiatric disorders [5].
Interestingly, DR3.CD8−/− mice with EAE showed decreased CNS pathology compared to DR3 mice thus suggesting a pathogenic role for CD8 T cells.
A potential pathogenic role for TTV has been suggested in immunocompromised patients with hepatitis of unknown etiology sustained by strong proinflammatory cytokines.
Our findings demonstrate a pattern of robust demethylation of interferon signature genes in lupus patients supporting a pathogenic role for neutrophils in lupus.
Despite a clear pathogenic role for mutant huntingtin, understanding huntingtin expression during the presymptomatic phase of the disease or during disease progression has remained obscure.
Accumulating evidence suggests a pathogenic role for IL-23 in inflamed epithelial tissues.
Splenic enlargement (splenomegaly) develops in numerous disease states, although a specific pathogenic role for the spleen has rarely been described.
CC was significantly more frequent in the group with than without LN, suggesting a pathogenic role for inclusions.
Such a pathogenic role for FasL appears to be in conflict with its purported role in immune privilege.
However, a possible pathogenic role for UCP2 protein in the development of human congenital hyperinsulinism or of any human disease has not yet been investigated.
A finding of renal hypoplasia in Gli3−/− mice suggests a pathogenic role for reduced GLI3 repressor in the Ptc1−/−UB mice.
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