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The transgenic animals, by allowing the exploration of uncharted territories, have revealed new pathogenic possibilities, although many of these cannot yet be proven in the human.
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Secondly, as a kind of conditional pathogenic bacteria, the possibility that healthy carrier sows harbor S. suis 2 is capable of causing disease under specific circumstances cannot be ruled out [ 5], suggesting a close linkage of S. suis serotype 2 from healthy sows and diseased pigs.
For instance, the microbial guideline states that coliform bacteria must not be detectable in 100 ml samples of water to be considered as safe and their presence in drinking water indicates the possibility of pathogenic bacteria.
Second, we considered the possibility that pathogenic mutations matching ancestral states may represent benign polymorphisms erroneously identified as pathogenic.
The identification of a potentially dominant pathogenic epitope raised the possibility of a 'magic bullet' approach for selective therapy in myasthenia gravis.
Williams et al. (1998) also showed that Opa+ N. gonorrhoeae bind to intracellularly located pyruvate kinase in infected cells further suggesting the possibility of pathogenic Neisseriae utilizing intracellular targets which may require their escape from the phagocytic vacuole.
We subsequently explored the possibility that pathogenic GCH1 variants could contribute to the risk of developing Parkinson's disease, even in the absence of a family history for DOPA-responsive dystonia.
With sequencing of entire genomes of some pathogenic leptospira species, the possibility of isolating sequences that might code for membrane proteins that are potential candidates for vaccine development has opened up.
The possibility of pathogenic changes being within the promoter, intronic or untranslated non coding regions of these genes playing a role in the pathogenesis of FECD has not been excluded in this study.
Although it is tempting to conclude that SLE has defects in 'checkpoints against autoimmunity' that explain the development of pathogenic IgG autoantibodies, the possibility cannot be excluded that these 'checkpoints' are active in SLE to prevent serious autoimmunity but are simply overwhelmed by chronic polyclonal B-cell activation.
As the most tropical sea cucumbers feed on live microorganisms and the organic contents found in sand or slime (Rowe 1969), there is the possibility that some pathogenic microorganisms are taken together with the food substances.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com