Our model provides interesting insights into the pathogenic nature of these opportunistic facultative intracellular pathogens and also shows the reaction of the innate immune system to an infection in real time.
Clostridium species are gram-positive, anaerobic, spore-forming bacteria and some species have pathogenic nature.
Due to the pathogenic nature of STEC, controls are not readily available and cell culturing of STEC reference strains requires biosafety conditions of level 2 or higher.
Identification of patients sharing a genomic rearrangement and having phenotypic features in common leads to greater certainty in the pathogenic nature of the rearrangement and enables new syndromes to be defined.
Given the highly pathogenic nature of Y. pestis, the organism is regarded as a potential bioterrorism agent.
Given the highly pathogenic nature of this subspecies, the possibility that it has become established wild in the heartland of Europe carries significant public health implications.
Additionally it appears to have a significant role in its pathogenic nature, and likely represents a key component in the S. aureus regulatory network.
Additionally it appears to have a significant role in the pathogenic nature of S. aureus, and likely represents an additional, key component in the regulatory network of this organism.
Many components of avian H5N1 isolates have been attributed to the highly pathogenic nature of these viruses, including the H5N1 PB2 and NS1 proteins, which are not included in the H5N1-PR8 reassortant viruses used here.
Further, the differential induction of miR-155 by virulent versus less virulent Francisella subspecies suggests that differences in miR responses may at least partially explain the highly pathogenic nature of F.t. versus F.n.
However, the pathogenic nature of these associations remains elusive.
