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These 16 mutations might have pathogenic effect on lowland people for impairment on OXPHOS function35.
YopJ family members exert their pathogenic effect on cells by disrupting this posttranslational modification.
Meur, G. et al. Insulin gene mutations resulting in early-onset diabetes: marked differences in clinical presentation, metabolic status, and pathogenic effect through endoplasmic reticulum retention.
Our numerical simulations suggested a detrimental effect of IFN-γ alone and in synergism with IL-6 but no conclusive pathogenic effect of IL-6 and TNF-α alone.
By our experimental and mathematical modelling approach, we found that during coinfections this balance is lost due to the exaggerated amounts of pro-inflammatory cytokines causing a pathogenic effect on bacterial clearance.
In conclusion, by combining tailored experimental data and mathematical modelling our study suggested a strong detrimental effect of IFN-γ alone and in synergism with IL-6 but no conclusive pathogenic effect of IL-6 or TNF-α alone.
Several studies have attempted to identify the precise mechanism by which this locus exerts its pathogenic effect to increase the risk of CAD-related events.
Thus, SJP-SNU had no pathogenic effect on chicken embryos.
CONCLUSIONS: DUX4's pathogenic effect in FSHD may occur transiently at or before the stage of myoblast formation to establish a cascade of gene dysregulation.
Fungal strains showed higher pathogenic effect against insects from which they isolated as compared to others (Tanyeli et al. 2010 and Sonmez et al. 2016).
As example, animal origin carbon source is becoming of concern due to release of segments with pathogenic effect (El-Hendawy et al. 2008).
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