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Given that miRNAs are conserved, with regard to both evolution and function, our observation of a common lupus disease-associated miRNA expression pattern in murine lupus models is likely to have significant pathogenic, diagnostic, and/or therapeutic implications in human lupus.
In summary, this translational genomics study identified a pleiotropic module, which has key pathogenic, diagnostic and therapeutic roles.
In this study, we used a module-based approach to systematically investigate the pathogenic, diagnostic and therapeutic roles of pleiotropic genes.
We integrated genomic meta-analyses with prospective clinical studies to systematically investigate the pathogenic, diagnostic and therapeutic roles of pleiotropic genes.
Thus, we were prompted to analyze possible pathogenic, diagnostic and prognostic significance of IFI16 protein and anti-IFI16 antibodies in patients with pSS, a combined model of systemic autoimmune and chronic inflammatory disorder.
The aberrant production of a broad heterogeneous group of autoantibodies is a serological hallmark in SLE; a great effort has thus been made to understand the pathogenic, diagnostic, and prognostic value of these autoantibodies since they were discovered [ 2– 4].
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Identification of these molecular targets provided pivotal insight into the pathogenic process, diagnostic assays and potential therapeutic strategies [2].
However, further basic or clinical studies are needed to test the pathogenic or diagnostic values of LCN2 expression.
Recently, CD has markedly changed due to considerable advances in the knowledge of its pathogenic and diagnostic aspects [ 1, 2].
Moreover, the pathogenic and/or diagnostic relevance of RBP4 in ICU patients is presently not known [ 15].
For example, the missense variant CREBBP p.N1978S is previously reported as pathogenic and diagnostic for Rubenstein Taybi syndrome (RTS) (Roelfsema and Peters, 2007).
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