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Each pathogenic criterion is weighted as very strong (PVS1), strong (PS1 4); moderate (PM1 6), or supporting (PP1 5) and each benign criterion is weighted as stand-alone (BA1), strong (BS1 4) or supporting (BP1 6).
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One system is consistent with the approach presented here and the other a point system whereby each criterion is given a number of points, assigning positive points for pathogenic criteria and negative points for benign criteria, with the total defining the variant class.
With stringent criteria, pathogenic SNVs and InDels were identified and patients with no pathogenic variants were further analysed for copy number variations (CNVs).
In families that meet the stringent Amsterdam criteria, pathogenic MSH2 or MLH1 mutations have been detected in about 50% of kindreds (Wijnen et al, 1997).
[1] Of particular importance in context of the present study are criteria linked to development of kidney disease: Production of potentially pathogenic anti-dsDNA antibodies (criterion # 10) and deposition of chromatin-containing immune complexes in kidneys (criterion # 7).
Therefore, the developed final equations would be adequate to compare the UV-H resistance of the different microorganisms and to define the processing conditions (process criteria) to achieve a certain level of pathogenic microbial inactivation (performance criteria), as will be discussed later on.
Thought needs to be given to the appropriate criteria when defining "infection" of the host by the pathogenic agent, and the criteria of what constitutes a clinical "case".
We also built two alternative test sets by varying criteria of pathogenic ncSNVs.
To define variants as "expected pathogenic" we used the criteria previously described.
For samples recruited through kConFaB, AJBCS and ABCFS, mutations were classified as pathogenic according to the criteria established by kConfab.
This information will allow for the development of genetic and genomic criteria for pathogenic strains, including development of assays that specifically detect pathogenic Listeria strains.
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