These techniques have enabled profiling of the gene expression of both the host and the pathogen, as well as identifying critical players that are differentially expressed under different pathogenic conditions associated with BRD.
Hence, we examined JMJD2B expression under the pathogenic conditions of hepatic steatosis induced by LXR signaling.
Autophagic induction in pathogenic conditions could have substantial benefits of therapy, including the degradation of cytotoxic materials, such as misfolded protein aggregates.
Variation in this gene is responsible for a wide range of neurological pathogenic conditions such as aggressive behaviour31, obsessive-compulsive disorder32, depression and autism33,34.
Under pathogenic conditions, where parkin is inactivated, PARIS levels increase, which leads to mitochondrial dysfunction through down-regulation of PGC-1α and eventually results in the loss of dopamine neurons that is PARIS-dependent15.
To accurately model development and pathogenic conditions at later stages, researchers need to generate and map more-mature human brain organoids that can gain additional features of the developed organ.
As we better understand the normal homeostasis among the maternal immune system, placenta, and commensal, we will be able to elucidate pathogenic conditions and design better approaches to treat pregnancy complications associated with infection.
Cholesterol is the main cargo in low and high-density lipoprotein complexes (i.e. LDL, HDL) and is directly implicated in several pathogenic conditions such as coronary artery disease which leads to 17 million deaths annually.
The hemodynamic response to exercise is affected by diverse factors such as age, gender and exercise load as well as concomitant pathogenic conditions including smoking, hyperlipidemia, hypertension and possibly diabetes.
We address therapeutic approaches based on the principles of synthetic immunology that either ameliorate disorders of the immune system by interfering with the immune response, or improve diverse pathogenic conditions by exploiting immune cell effector functions.
However, future studies are necessary to further validate the use of nasal cells in studying other pathogenic conditions of lower airways such as exposure to additional cytokines, allergens and other pathogens including respiratory viruses.
