Sentence examples for pathogenic changes from inspiring English sources

The variations were regarded as pathogenic changes as long as they met the criteria of pathogenicity, i.e absence in 200 control individuals and the segregation with the disease phenotype within the family (Fig. 4).

Here we have used lens transcriptome profiling by microarray-hybridization and qPCR to identify pathogenic changes during cataract development in Mip-mutant (Lop/+) mice.

Therapeutic intervention using proteostasis/autophagy inducing drugs may mitigate the SHS exposure-mediated pathogenic changes initiating pediatric lung diseases such as bronchopulmonary dysplasia (BPD) or adult COPD-emphysema-like childhood condition.

Moreover, the pathogenic changes of both liver architecture and vascularisation in cirrhotic livers, as well as the lack of "true-to-life" in vitro models have impeded the development of an effective anti-fibrogenic drug.

Finding common pathogenic changes originating from these risks may lead to a new therapeutic strategy.

Using an optimized DNCB sensitization scheme (Figure 1A), we then characterized the pathogenic changes in the back and ear skins.

As with benign variants, pathogenic changes are segmental, altering ∼kilobase to whole-chromosome-sized stretches of DNA.

The pathogenic changes underlying autoimmune disorders are thought to be initiated and driven by T cell populations that recognize and respond to autoantigens [19].

Owing to hundreds of alterations that might be merely consequential to transformation, the use of in vitro model of human cells expressing known oncogenes was proposed as a useful approach to focus on the pathogenic changes displayed by tumors.

All these pathogenic changes were prevented by Zn supplementation.

However, no pathogenic changes were found in any of the genes analysed.