Sentence examples for pathogenic by from inspiring English sources

Only three were predicted as pathogenic by at least 2 out of the 4 in silico pathogenicity predictors used and 1 was a truncating mutation.

A total of 28/63 MLH1 and MSH2 variations are indicated as pathogenic by both in silico methods and in 24 of them pathogenicity is further supported by STEP3 results.

Of all coding missense substitutions in the RMA list, 264 were annotated as potentially pathogenic by all three tools after our correction, which is in sharp contrast to only nine in the dbNSFP database (Figure 1e).

This loop appears to be a new mechanism (possibly pathogenic) by which fructose consumption rapidly becomes highly lipogenic and deleterious.

However, Bb is the first bacterium of this genus found to be highly pathogenic by natural infection for the silkworm in the sericulture production.

This regulatory control loop appears to be a new mechanism (possibly pathogenic) by which fructose consumption rapidly becomes highly lipogenic and deleterious by increasing adiposity.

Furthermore, FTDP-17 mutations have been described that do not alter the primary sequence of tau or the total tau levels expressed, but rather appear to be pathogenic by simply altering the ratio of 3R and 4R tau found in the brain [9] [12], often by destabilizing the exon 10 stem loop structure and increasing exon 10 expression [26].

Frameshift mutations were classified as pathogenic when reported as pathogenic by BIC and/or predicted as pathogenic by SIFT Indel.

These mutations would likely be pathogenic by the mechanism of haploinsufficiency as reported [ 21].

This mutation was confirmed to be pathogenic by several studies [ 10, 42, 43].

Here, all AASs classified as pathogenic by PON-P2 are considered to be harmful.