In Aspergillus fumigatus, a filamentous human pathogenic fungus, analysis of the small transcriptome (15 - 500 nt) revealed that 23% of the sequences corresponded to tRNA or halves of mature tRNA (36 - 39 nt) [ 9].
Assuming that non-synonymous mutations would mark recent evolution, and hence be associated to the onset of the pathogenic process, analysis of ratios of non-synonymous SNPs vs synonymous SNPs suggested hypotheses about possible pathogenicity determinants.
For the purposes of this analysis, pathogenic mutations include frameshift mutations, pathogenic splice variants, large rearrangements, or missense mutations classified as pathogenic by Breast Cancer Information Core [ 15].
For DE analysis, pathogenic isolate (FO40) was compared against non-pathogenic isolate (FO36) at each time point.
Since stress response genes play critical roles in the virulence of other pathogenic bacteria, the analysis of responses to environmental stresses could add to our understanding of T. denticola mediated pathogenic events [7], [19].
If a small population of monomer-misfolded SOD1 is pathogenic in FALS, analysis should be difficult when using homodimeric mutant SOD1 like the mutant SOD1G93A as the majority of homodimeric protein has merely a bystander role.
In this first analysis, pathogenic mutations were not detected in the IRAK4 gene.
Therefore, the proteome of the milk may drastically change in response to pathogenic stimuli, and analysis of these changes may offer insight into the host response during mastitis.
In addition to the complete genomic sequence information for pathogenic bacteria, CGH analysis was useful as one of the approaches based on reverse vaccinology [ 56] for screening vaccine candidates against leptospirosis.
In coincidence with our analysis, pathogenic S. suis could effectively resist the uptake by phagocytes and CPS could inhibit activation of signaling pathways involved in phagocytosis [ 17, 71, 72].
