Sentence examples for pathogenic alteration from inspiring English sources
Thus, both pro- and anti-apoptotic forces seemed to be induced in cattle with MCF, which might lead to a pathogenic alteration in the natural balance between cell survival and cell death.
Microglia-derived oxidative stress bridged neuroinflammation and α-syn pathogenic alteration in mediating chronic PD progression.
We therefore created a chronic, two-hit mouse model to investigate whether inflammation enhances α-syn pathogenic alteration and accelerates neurodegeneration and disease progression.
In the present study, we did not find any pathogenic alteration in 10 families that included patients with breast, gastric or colon cancer.
Finally, SNP 6.0 called six pathogenic CNVs (6/139, 4.3%) while Omni1 called five (5/35, 4.7%) and CytoSNP called four (4/8, 50%), but these all correspond to the same four pathogenic alterations that were fragmented into smaller segments by SNP 6.0 and Omni1, thus none of the tested arrays identified a pathogenic alteration that was undetected by the other arrays.
Chronic hyperglycemia, a pathogenic alteration characteristic of 2DM, also causes endogenous ROS increase by inhibiting glycolysis and promoting the formation of harmful intermediates such as advanced glycation end products (AGEs) and protein kinase-C pathway (PKC) isoforms, which have DNA and protein damaging effects [ 27, 28].
This resulting mutational landscape shows medically actionable pathogenic alterations to optimize antitumor therapy.
In patients with either primary or metastatic sporadic disease, we sought to determine the frequency of KIT and PDGFRA pathogenic alterations within such specimens, imatinib sensitivity, and the concordance of pathogenic alterations between paired specimens.
Here, we review a set of newly discovered pathogenic alterations and discuss the structural repercussions of debilitating mutations on desmosomal proteins.
Second, palmitate-induced pathogenic alterations were consistently alleviated by a mono-unsaturated FFA.
In this hypothesis (H1 + H2), OS and secondarily induced CS cause pathogenic alterations in SCZ.
