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In fact, these two glia cells may play distinct roles in Aβ clearance depending on amyloid aggregation states and pathogenesis stages.
Separate analyses were conducted for each outcome of the HIV-1 pathogenesis stages and only previously confirmed and validated (in other cohorts) genetic and non-genetic factors were adjusted for in the analyses.
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Whether IL-17-producing Th cells exert pathogenic or protective effects depends partly on coexpressed cytokines, tissue-specific factors, and the pathogenesis stage.
The results of all studies mentioned are summarized in Tables 1 and 2. All of those who have investigated the association between TLR gene polymorphisms and features of prostate cancer pathogenesis (stage, aggressiveness, Gleason grade, metastases), as well as the association between TLR gene polymorphisms and prostate cancer mortality, obtained negative results.
It could give new insight into the pathogenesis and staging of the disease which could help in the effective planning of treatment.
The potential identification of any prognostic marker of canine cardiac disease would be of great importance since it may not only give new insight into the pathogenesis or staging of the disease but also help in the effective planning of treatment.
MD pathogenesis involves multiple stages including an early cytolytic phase and latency, and transitions between these stages are governed by several host and environmental factors.
Efforts have been made to identify the genes involved in pathogenesis at various stages of the disease in both in vivo and in vitro models by microarray analysis of brain tissue [2] [6].
The current model of NASH pathogenesis proposes two stages of progression.
This animal model could be used for studying pathogenesis of early stages of the disease including preclinical changes and to test therapeutic action of drugs.
Hence, our data argue for a pivotal role of HIF-1 α in the pathogenesis of later stages of human gastric cancer and its systemic spread.
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