Exact(1)
In many cases, these types of studies are correlated with quantification of pathogen load and descriptions of disease pathogenesis, signs and gross lesions.
Similar(59)
Under experimental conditions, however, small ruminants are susceptible to BSE, with pathogenesis and clinical signs that are not readily distinguishable from scrapie (9 – 12 ).
Ferrets are the preferred animal model for influenza transmission studies because clinical signs, pathogenesis and sialic acid distribution are similar in ferrets and humans (Maher and DeStefano, 2004; Shinya et al., 2006; Bouvier and Lowen, 2010).
Following intracranial inoculation into nude mice, the miR-124-sensitive vector failed to replicate or show overt signs of pathogenesis.
In combination, clinical, pathological, modified influenza A matrix gene real time RT-PCR and viral genomic analyses have shown that infection results in the induction of clinical signs, viral pathogenesis restricted to the respiratory tract, infection dynamics consistent with endemic strains of influenza A in pigs, virus transmissibility between pigs and virus-host adaptation events.
In this study we have shown that pigs can be readily infected with pandemic (H1N1) 2009 virus (A/California/07/09), resulting in the induction of clinical signs, viral pathogenesis restricted to the respiratory tract, infection dynamics consistent with endemic strains of influenza A in pigs, virus transmissibility between pigs (four cycles) and virus-host adaptation events.
However, the overabundant productions of inflammatory responses are responsible for the signs and pathogenesis of influenza infection [ 47, 48].
In this study, we sought to evaluate the clinical usefulness of a classification scheme of CES based on various factors including etiology, pathogenesis, clinical symptoms, imaging signs, and electrophysiological findings for the purpose of proper clinical management.
10 Synaptic dysfunction, manifested by myoclonus and seizures, is one of the earliest signs of pathogenesis in patients with neurodegenerative disorders including INCL. 4, 11 Despite intense studies, a precise molecular mechanism(s) of synaptic dysfunction in INCL remains largely unclear.
An infection-like process exerted by the consortium could be hypothesized; however, nematodes grown with MBC microbiota did not show intestinal lumen distension (data not shown), a characteristic sign of pathogenesis [ 33].
To the best of our knowledge, this is the first report of a case in which an endovascular aneurysm repair (EVAR) for an abdominal aortic aneurysm was complicated by an abdominal aortic false aneurysm which caused severe erosion of two lumbar vertebral bodies and disc through an inflammatory mechanism, without signs of infective pathogenesis.
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