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However, improvements in our understanding of signaling pathways involved in the pathogenesis, growth, and spread of NETs have translated into an expansion of treatment options.
Deregulation of calcium signaling is regarded as the primary event in the pathogenesis, growth, invasion, and secondary spread of cancer [ 44].
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We investigated the role of cytokines, in particular interleukin (IL -8, IL -8e pathogenesin of growthehormone (GH) pathogenesismofrs.
To consider the pathogenesis and growth of cavernous hemangioma, particularly within the crowded orbital apex, in decisions regarding surgical indications, timing, and technique.
Lately, CpG islands of Axin2 were found methylated in human neuroendocrine tumors (NETs) and Axin2 expression is correspondingly downregulated, which may contributes to the pathogenesis and growth of NETs (Kim et al., 2013a).
These molecules have also been reported to affect Aeromonas spp. pathogenesis and growth [12], [16], [18].
c-MET is implicated in the pathogenesis and growth of a wide variety of human malignancies, including colorectal cancer (CRC).
Sex steroid hormones have previously been implicated in the pathogenesis and growth regulation of ovarian cancers (Hoover et al, 1977; Langdon et al, 1990; Godwin et al, 1993; Chien et al, 1994).
Our results indicate that there is a higher circulatory frequency of Th22, Th17 and Th1 cells in CC which may conjointly participate in the pathogenesis and growth of CC.
The pathogenesis of growth failure in thalassemia is multifactorial and is mainly due to transfusional iron overload and resulting endocrinopathies (GH deficiency, hypothyroidism diabetes), nutritional deficiencies, and intensive use of chelating agents particularly desferrioxamine.
Since Okamoto et al [ 4] proposed, for the first time, a possible role of the podoplanin in tumor invasiveness of keratocystic odontogenic tumors, further investigations have been conducted in order to understand the exact function of this protein in the pathogenesis and growth of these benign tumors [ 5, 8– 17, 17].
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