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As with research in common disease susceptibility, the path to translation involves a two stage process that first requires the reliable identification of the genetic loci involved, and then research into the healthcare applications of this knowledge, which includes critical appraisal of the performance of genotype as a predictive test.
However, the selective forces underlying the emergence of the translation system in the RNA World remain obscure, and tracing the path to translation is extremely hard.
The focus of this review is to describe the status of development of cell and gene therapies and the path to translation outside of the academic realm and into licenced, marketable medicines.
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However, a step back is never taken with enthusiasm, and when there are more direct paths to translation through new technologies, it is paramount that we pursue those paths, translational and foundational, in parallel.
The development of cells for regenerative therapy has encountered many pitfalls on its path to clinical translation.
It is increasingly obvious that similar well-established industries implement automated robotic systems on the path to commercial translation and economic success.
The long controversy surrounding the use of paternal allo-immunization as a treatment for miscarriage patients resulted from incomplete understanding of the relevant biological mechanisms and failure to engage the correct path to clinical translation (Porter et al., 2006).
The use of a positron-emitting analog has certain advantages over an MR-based agent in that it will be administered in subpharmacologic, i.e. 'tracer', doses, enabling a smoother path to clinical translation.
The flexible translation of PD into AF and related interaction methods are an initial step in translating the different SBGN languages and open the path to future research for translation methods between other SBGN languages.
"Bollywood Hero," which begins Thursday and bills itself as a musical comedy, does not, on the face of things, seem like the most obvious path to something like "Lost in Translation," other than in its queasy, clunky borrowing of the film's vision of Hollywood disillusion and cultural displacement.
2. Given that the essence of translation is the intimate link between RNA and proteins, it seems most likely that, in some form, this connection existed from the very beginning of the evolutionary path from the RNA World to translation.
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