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The apparent inferiority of echinocandins as initial therapy in the PATH population stands in contrast to this recommendation; if the guideline is correct, the impact of unmeasured variables in our study would have to be sufficient to not only account for the observed survival difference but to reverse it.
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Obstacles were strewn on the path to population control.
For each path, a population of 5,000 type 2 diabetic patients was modeled over a period of 15 years.
In his view, the demographic transition ignored too many variables and too many historical developments that did not fit the theory (e.g. the postwar baby boom), as well as assuming a single path of population development based on socio-economic progress.
Faster convergences, better final points which satisfy all constraints imposed on the drilling paths and population diversity maintenance to help the algorithms find better solutions, are positive characteristics of the solutions found using the algorithms proposed.
Similar to split-route migration paths within populations, recent evidence shows that within coho [35], Chinook [3] and sockeye [2] populations along the outer coast from Oregon to southeast Alaska, fish fall into discrete groups with respect to migration speeds.
Yet, there is a much greater variability of migratory paths between populations.
In a similar manner, if admixture is sex-biased, because lineages are more likely to travel along paths through populations with the larger sex-specific contributions, the variability of genealogical paths and hence, the variance of the admixture fraction is reduced compared to the non-sex-biased case.
Second, while PATH is a population representative study in which participants were randomly selected into the neuroimaging substudy from the larger population-representative cohort, it may not be completely representative of the population at large.
And yet it has long been clear that the path to better population health in advanced economies passes through the kitchen and the gym rather than the doctor's surgery.
If no such escape route along a neutral path exists, a population is most likely to cross a fitness barrier where the barrier is narrowest, rather than where the barrier is shallowest.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com