Sentence examples for path of mutation from inspiring English sources
Other limitations of the study were (i) the lack of fitness values in the presence of drugs so that epistatic effects and their consequences could not be compared with and without medication and (ii) the lack of knowledge of the direct path of mutation accumulation including all intermediate mutants.
By extending node centrality metrics to paths of mutations (connected nodes in the network) I was able to study properties of adaptive evolutionary trajectories in TEM.
The algorithm returns an inferred phylogeny T for the given inputs N and p. Although the basic median-joining strategy can be adapted to this application as a way of heuristically solving the hard problem of Steiner node inference, that strategy still depends on having a way to accurately estimate likelihoods and reconstruct likely paths of mutations between pairs of taxa.
We first carry out a conventional landscape analysis and observe, next to a number of common features related to the interaction structure, important differences between the instances, such as the number of solutions, the quality of the paths to the solutions, and the lengths and extent of the neutral paths for mutation.
The purpose of this strategy is to maximize the search progress rate by reproducing the successful evolution path through the adaptation of mutation (i.e. step size and direction).
This path is ruled out for two reasons: first, no duplications of C+ S4 genes were observed in any of the 660 genomes studied, and second, the path depends on an unlikely set of mutation events.
Thus, multiple extinctions of small sub-populations may be an important evolutionary path of weeding out harmful mutations.
Natural selection operates on mutations, making the path of natural selection unpredictable, regardless of how well we understand the underlying principles.
These paths describe a set of mutations wherein the predicted expression pattern does not significantly vary at any point along the path.
Probability of mutation:0.01.
